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KMID : 0377520180430010023
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Chung-Ang Journal of Medicine
2018 Volume.43 No. 1 p.23 ~ p.29
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Iron Deficiency Anemia and Febrile Seizures in Children
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Kwon A-Ram
Lee Ran
Kwak Byung-Ok
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Abstract
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Purpose: Febrile seizures (FS) in young children (6~60 months old) are the most common type of seizure recorded in neurologically healthy infants and children, with a 2~5% incidence of at least one episode in this population. Iron-deficiency anemia (IDA) is defined by state of iron deficiency (ID), specifically serum ferritin <12 μg/L, and a hemoglobin (Hb) level <11 mg/dL. Iron is essential for proper growth and development. In addition to anemia, inadequate iron stores may culminate in growth and behavioral disorders, mental retardation, and impaired immune function. Because the peak ages for iron deficiency and for febrile seizures coincide, much research has been aimed at establishing a correlation.
Methods: Children (n=181; 6~60 months old) hospitalized with FS at Konkuk University Medical Center, Seoul, Korea between January, 2012 and December, 2012 was analyzed for this retrospective, case-control study. We chose ageappropriate values of MCV, RDW, and Hb to define ID and IDA in this study.
Result: Overall, 181 children with FS (boys, 100; girls, 81) and 181 control subjects were recruited for study. In our study, no significant differences in median values of hemoglobin, mean corpuscular volume (MCV), and red cell distribution width (RDW) between children with FS and age/gender matched controls. Respective rates of ID (3.3% vs. 2.8%) and IDA (2.8% vs. 2.8%) did not differ significantly. In subgroup analysis, comparing simple or complex FS subsets with controls, no significant differences in iron status were evident.
Conclusion: IDA had no impact on the risk of FS in young children. IDA is prevalent in this age group, therefore evaluation and treatment of IDA is considered irrespective of FS.
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KEYWORD
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Iron deficiency anemia, Febrile seizure, Pediatric, Child
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